Oral Nifedipine Versus Oral Labetalol

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study's aim is to determine whether oral extended release nifedipine is superior to oral labetolol for the management of postpartum severe hypertension, specifically time to achieve goal blood pressure, and shortening hospital stay. Our hypothesis is that oral extended release nifedipine is superior to oral labetolol for achieving goal blood pressure in the postpartum period.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cedars-Sinai Medical Center
• Treatments: Labetalol; Nifedipine

Criteria

Inclusion Criteria:

• Age ≥ 18 years with the abililty to give informed consent

• Intrauterine pregnancy ≥ 32 weeks

• Postpartum

• Persistent postpartum blood pressures ≥ 160/105 on two or more occasions

• Primary obstetrician amenable to starting either study medication in the postpartum period

Exclusion Criteria:

• Use of other oral antihypertensives concomitantly

• Known AV heart block

• HR <60 or >120

• Absolute contraindication to nifedipine or labetolol such as allergy

• Significant renal disease (Cr >1.5 mg/dL)

• Heart failure

• Moderate persistent or severe asthma

• Preexisting diagnosis of chronic hypertension with medical treatment before delivery

• Chronic hypertension