Oral Nitrite and Nitrate in Healthy Normal Volunteer Adults
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
This proposal hypothesizes that oral supplementation with sodium nitrite or nitrate will
result in in vivo conversion of nitrate to nitrite and nitrite to nitric oxide with limited
toxicity in the doses proposed in healthy adult normal volunteers. We utilize a powerful in
vivo technique (pharmacokinetic testing) and are the first to design inorganic nitrate and
nitrite capsules for cardiovascular disease.