Oral Penicillin and Penicillin Levels in Venous Umbilical Cord Blood

• Status: Terminated
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Pregnant,laboring women will receive 2 grams of oral penicillin V before delivery. At the time of delivery of the infant, umbilical vein cord blood will be obtained from the umbilical cord. These cord blood samples will be sent for bioassay of penicillin levels.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: William Beaumont Hospitals
• Treatments: Penicillin V; Penicillins

Criteria

Inclusion Criteria:

• pregnant women admitted for delivery or for induction of labor

• singleton pregnancy

• 18 years old or older

• beyond 36 weeks gestation

• able to comprehend study and give informed consent

Exclusion Criteria:

• known history of beta-lactam antibiotic allergy

• impaired renal function

• multiple gestation

• current use of antibiotics

• plan to bank cord blood after delivery