Oral Pregabalin Premedication for Postoperative Pain Relief
Status:
Recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
Pain management after gynecological surgeries is essential for early mobilization of the
patient, decrease postoperative complication and hospital stay. The use of opioids is
associated with adverse effects such as nausea, vomiting, ileus, pruritus, sedation and
respiratory depression.
Previous studies stated that pregabalin has been used to reduce pre-operative anxiety, acute
postoperative pain, postoperative opioid requirements, postoperative nausea, vomiting and
postoperative delirium. The most effective dose of pregabalin to relief postoperative pain
with least side effect is still under trial.
In this study we will compare between two different doses of pregabalin when given as oral
premedication in patients undergoing gynecological surgeries under spinal anesthesia
regarding postoperative pain in order to reduce opioids consumption and subsequently avoid
opioid-related adverse effects.