Oral Pregabalin Premedication for Postoperative Pain Relief

• Status: Recruiting
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

Pain management after gynecological surgeries is essential for early mobilization of the patient, decrease postoperative complication and hospital stay. The use of opioids is associated with adverse effects such as nausea, vomiting, ileus, pruritus, sedation and respiratory depression.

Previous studies stated that pregabalin has been used to reduce pre-operative anxiety, acute postoperative pain, postoperative opioid requirements, postoperative nausea, vomiting and postoperative delirium. The most effective dose of pregabalin to relief postoperative pain with least side effect is still under trial.

In this study we will compare between two different doses of pregabalin when given as oral premedication in patients undergoing gynecological surgeries under spinal anesthesia regarding postoperative pain in order to reduce opioids consumption and subsequently avoid opioid-related adverse effects.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zagazig University
• Treatments: Ascorbic Acid; Pregabalin

Criteria

Inclusion Criteria:

• Physical status: ASA I-II

• BMI ≥ 20kg/m2 & ≤ 35kg/m2,

• Written informed consent from the patient.

Exclusion Criteria:

• Patients with known history of allergy to study drugs,

• Patients on ACE inhibitors, anticonvulsant therapy or any drug interacting with pregabalin,

• Patients on chronic alcohol, opioid, tranquilizer or sedative use,

• Patient with renal impairment or heart failure,

• Pregnant females, Psychological, mental disorders or depression,

• Patients receiving anticoagulants therapy or suspected coagulopathy,

• Patients already on pregbalin or gabapentin therapy.