Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma

• Status: Completed
• Trial end date: 2017-04-02
• Target enrollment: 0
• Participant gender: Female

Summary

This study assess the effectiveness of oral tranexamic acid in combination with hydroquinone cream in the treatment of melasma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fakultas Kedokteran Universitas Indonesia
• Treatments: Hydroquinone; Sunscreening Agents; Tranexamic Acid

Criteria

Inclusion Criteria:

• moderate melasma (subject with mMASI score of 5 to 7.9),

• severe melasma (subject with mMASI score ≥ 8),

• willing to follow up for 6 months.

Exclusion Criteria:

• pregnant women,

• nursing women,

• women on exogenous hormones

• current treatment with blood thinners,

• had a history of thrombosis,

• had an abnormal kidney function,

• use of topical hydroquinone within 3 months of study enrollment,

• use of topical steroids, vitamin A analogs, chemical peels within 1 month of study