Overview

Oral Versus Patch Hormonal Contraceptive Effects on Metabolism, Clotting, Inflammatory Factors and Vascular Reactivity

Status:
Unknown status

Trial end date:
2011-12-01

Target enrollment:

Participant gender:

Summary

The purpose of this study is to compare the effects of oral versus patch administration of hormonal contraception on hormone sensitive proteins such as lipoproteins, clotting factors and inflammatory proteins as well as blood sugar and insulin levels, antioxidant status and flow-mediated dilation of arm and forearm vessels. The hypothesis is that oral administration of contraceptive hormones will result in higher plasma levels of estrogen sensitive proteins originating from the liver while patch administration of contraceptive hormones will result in greater systemic effects of estrogen on vascular reactivity and antioxidant status.

Phase:

Phase 2

Details

Lead Sponsor:

University of Washington

Collaborator:

Ortho-McNeil Pharmaceutical

Treatments:

Ethinyl Estradiol
Fluoroquinolones
Moxifloxacin
Norgestimate, ethinyl estradiol drug combination
Ortho Evra