Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
Status:
Completed
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to treat patients with a diagnosis of chronic rhinosinusitis
(CRS) and a history of bilateral endoscopic sinus surgery during times of worsening symptoms
and signs of acute infection on nasal endoscopy with one of two treatments: (1) oral
antibiotics and twice daily intranasal saline irrigations or (2) oral placebo and twice daily
intranasal antibiotic irrigations. The two treatments will be compared to see if there is any
difference in patient outcomes. This will help guide treatment strategies for patients with
CRS in the future.