Oral vs Initial Intravenous Antibiotic Treatment of Urinary Tract Infections in Children: a RCT

• Status: Terminated
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objectives of the study are

1. to compare the efficacy of oral vs initial iv antibiotic treatment in children with a first episode of UTI

2. to assess the diagnostic power of the various imaging technique (renal ultrasonogram, voiding cystourethrogram, and renal scanning with technetium-99m-labeled dimercaptosuccinic acid)

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Padova
• Collaborators: IL Sogno di Stefano; Regione Veneto
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Ceftriaxone; Clavulanic Acid; Clavulanic Acids

Criteria

Inclusion Criteria:

• age between 2 months and 6 years,

• normal renal function

• first episode of upper UTI (fever, 2 consecutive positive urinalysis, later confirmed by 2 cultures and high blood inflammation indices)

Exclusion Criteria:

• documented previous urinary tract malformation (prenatal ultrasound)

• seriously compromised general conditions (such as sepsis or vomit)

• hypersensitivity to the antibiotics considered.