Organ Protective Effect of Cetirizine In Patients With Severe Burns

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This prospective clinical trial aims to investigate the organ protective effects of cetirizine in patients with severe burns.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ruijin Hospital
• Treatments: Cetirizine; Fentanyl; Midazolam

Criteria

Inclusion Criteria:

• Signed and dated informed consent form

• Commitment to comply with the procedures and cooperation during the course

• TBSA >30% and admitted within the first day after burns

• No severe compound injuries

Exclusion Criteria:

• History of allergy to drugs in the trial

• Postoperative complications that would interfere with the observation

• Mental illness and severe heart disease, hypertension

• Serious genetic diseases

• Incomplete clinical information (unclear diagnosis, incomplete medical history, incomplete medication records, etc.)

• Pregnancy/lactation

• Malignant tumors

• Organ insufficiency due to previous chronic diseases such as hypertension, diabetes mellitus or non-burning factors

• Serious adverse reactions

• Self-requested withdrawal