Oro-tracheal Intubation: Flurbiprofen Subglottic Instillation to Prevent Laryngeal Inflammation
Status:
Not yet recruiting
Trial end date:
2022-01-31
Target enrollment:
Participant gender:
Summary
Most efficient system for airways controll during general anesthesia is oro-tracheal
intubation, in order to allow mechanical ventilation and bronchial suction and to prevent
gastric intake. However, in the period after exhumation, traumatism of tube placement causes
in 21% to 72% of patients, sore throat (POST), generally associated hoarseness. The incidence
of POST is influenced by numerous factors such as age, smoke history, duration of tube
positioning maneuvers, diameter of the endotracheal tube, pressure present in the headset,
duration of intubation. Although analgesics and systemically administered anti-inflammatories
have been found to be effective, topical therapies based on the application of
corticosteroids, NSAIDs and lidocaine are an interesting alternative because they are also
effective, but devoid of the effects collateralises of systemic administration. The proposed
methods for the prevention and treatment of POST in cardiac surgery patients, subjected to
long-term interventions with consequent need for prolonged mechanical ventilation and
therefore orotracheal intubation even in the post-operative period. The propose of trial is
that the sub-glottal intake door can also be used for the peat administration of
anti-inflammatory drugs in order to prevent pain caused by endotracheal intubation. This drug
thus administered will directly reach the anatomical structures most involved in the genesis
of post-intubation pain, that is, the vocal cords and the expected part of the trachea.