Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients
Status:
Active, not recruiting
Trial end date:
2021-09-20
Target enrollment:
Participant gender:
Summary
Muscle cramps are commonly affects patients with cirrhosis. It adversely influences the
quality of life of cirrhotic patients. Treatment of muscle cramps still challenging owing to
the diversity of the responsible pathophysiological mechanisms.The effectiveness of baclofen
and orphenadrine in controlling muscle cramps in cirrhotic patients has been presented in
recent randomised controlled clinical trials;however, the comparative efficacy and safety
between these two therapeutic options has not been previously investigated.