Orphenadrine Versus Baclofen in Treatment of Muscle Cramps in Cirrhotic Patients

• Status: Active, not recruiting
• Trial end date: 2021-09-20
• Target enrollment: 0
• Participant gender: All

Summary

Muscle cramps are commonly affects patients with cirrhosis. It adversely influences the quality of life of cirrhotic patients. Treatment of muscle cramps still challenging owing to the diversity of the responsible pathophysiological mechanisms.The effectiveness of baclofen and orphenadrine in controlling muscle cramps in cirrhotic patients has been presented in recent randomised controlled clinical trials;however, the comparative efficacy and safety between these two therapeutic options has not been previously investigated.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Baclofen; Orphenadrine

Criteria

Inclusion Criteria:

1. Age 18-70 years

2. Cirrhotic patients complaining of frequent muscle cramps (>3 per week) for at least a month

Exclusion Criteria:

1. Patients with allergy to study drugs

2. Renal impairment

3. Peripheral vascular disease

4. Peripheral neuropathy

5. Glaucoma

6. Prostatic enlargement

7. Pregnancy and lactation

8. Patients taking calcium channel blockers, and conjugated estrogens

9. Patients taking vitamin E, taurine, carnitine, narcotic pain medications, muscle relaxants, nonsteroidal anti-inflammatory drugs, or antispastic agents during and for 2 weeks following the study

10. Patients with alcoholic cirrhosis