Oslo Antioxidant Study

• Status: Completed
• Trial end date: 2005-03-01
• Target enrollment: 0
• Participant gender: Male

Summary

The primary objective of this study is to test whether increasing the total intake of antioxidants to middle-aged smoking men increases the antioxidant defence, reduces oxidative damage, and improves biomarkers for oxidative stress.

The secondary objectives is to test whether this strategy improves other cardiovascular risk markers including platelet function, lipid levels, inflammation, and markers of endothelial damage.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oslo
• Collaborator: Ullevaal University Hospital
• Treatments: Antioxidants

Criteria

Inclusion Criteria:

• Men aged 45-75 years

• Daily smoker of a minimum of 5 cigarettes a day

• BMI <35 kg/m2 (because of difficulties that may be experienced by morbidly obese individuals in following the diet)

• Stable weight range of 4 kg or less during the previous 12 weeks

Exclusion Criteria:

• Any symptomatic CVD (myocardial infarction, angina pectoris, CABG, PCI, CHF, NYHA class III-IV)

• Diabetes type I or type II taking drugs for diabetes

• Following a vegetarian diet or near-vegetarian diet currently

• Allergy to nuts, kiwi fruits, chocolate, strawberries or tomatoes

• Clinical disorders including gastrointestinal disease impairing compliance with dietary recommendations

• History of serious or unstable medical or psychiatric disorder

• Current use of or need of lipid lowering drug treatment, aspirin or non-steroidal anti-inflammatory drugs (NSAID), according to assessment of the primary clinical investigator. Any "over the counter" headache/ pain or cold remedies taken during the study must not contain aspirin or aspirin like drugs such as ibuprofen. These are classed as and will interfere with platelet function, making them unresponsive for a period of 10-14 days. Paracetamol, however, can be taken as an alternative if required

• History of alcohol/or drug abuse

• Participation in a drug trial during the previous 30 days

• Use of drugs (Xenical, Reductil), nutritional supplements or herbs for weight loss within the 4 weeks prior to visit 2 or participation in an active weight reduction program

• Use of single vitamin or other antioxidants (must be stopped 4 weeks prior to visit 2)

• Individuals judged by the clinical investigator to be unable to follow instructions and procedures of the study.