Outcome of Neoadjuvant Chemotherapy for Obstructive Colon Cancer
Status:
Not yet recruiting
Trial end date:
2027-10-31
Target enrollment:
Participant gender:
Summary
In this study, patients with obstructive colon cancer will be divided into two groups; in the
control group, curative surgery will be performed within 2 weeks after successful SEMS
placement, and in the experimental group, 3 cycles of neoadjuvant chemotherapy will be
administered into patients who undergo successful SEMS placement and then curative surgery
will be performed after neoadjuvnat chemotherapy. After the surgery, adjuvant chemotherapy
will be administered, and total perioperative chemotherapy will be administered with 12
cycles. The primary end points is overall survival, also the short-term perioperative
outcomes and long-term oncological outcomes will be compared between the control and
experimental group. Random allocation will be carried out with the consent of patients and
their guardians after successful SEMS placement, and 204 patients will be distributed between
the two groups by 1:1.