Outcomes of AVS With or Without ACTH Stimulation in PA

• Status: Recruiting
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To compare the effect of different procedures of AVS(with or without ACTH stimulation) on the long-term outcomes of patients with PA

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chongqing Medical University
• Treatments: Adrenocorticotropic Hormone; beta-Endorphin; Cosyntropin; Hormones; Melanocyte-Stimulating Hormones

Criteria

1.Inclusion criteria: Patients who meet the following criterion can be included in this study.

1. Hypertension patients with positive PA screening (ARR>20) and at least one positive PA confirmatory test (PAC-post CCT>110pg/ml, PAC-post SSIT >80pg/ml, or PAC-post FST>60pg/ml);

2. Willing to undergo AVS;

3. Understand the whole process of the trial and voluntarily accept randomized grouping, intervention and follow-up;

4. Voluntarily participate in the study and sign the informed consent form;

5. Aged between 18-70, male or female, with legal capacity;

2.Exclusion criteria: Patients with one of the following conditions will be excluded in this study:

1. Pregnant or lactating women;

2. Refusal to undergo unilateral adrenalectomy;

3. Allergic to ACTH or contrast media;

4. PA combined with Cushing syndrome (including subclinical Cushing): Cortisol was greater than 140nmol/ L after 1mg DST;

5. Familial PA;

6. Treatment with glucocorticoids and cannot be stopped;

7. Complicated with disease which contraindicated to unilateral adrenalectomy or seriously interfere with subsequent treatment of PA or health-related quality of life assessment, such as severe heart disease (including pacemaker implantation), severe cardiac dysfunction, severe anemia (Hb<60g/L), stroke or acute coronary syndrome within 3 months, severe ascites and liver cirrhosis, malignant tumors;

8. Alcoholics, drug users, and mentally disabled patients;

9. CT does not exclude pheochromocytoma or cortical carcinoma.