Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Patients diagnosed with NAION within 14 days of onset were included. Patients were randomized
into 3 groups. Group 1 or control consisted of 30 patients who received gelatinous capsules
filled with sugar as placebo. Group 2 or steroid consisted of 30 patients received
methylprednisolone (Solu-Medrol, Pharmacia Pharmaceutical Company, Belgium) 500 mg twice a
day for 3 days followed by 2 weeks of oral prednisolone 1mg/kg/day. Thirty patients in group
3 or oxygen received 100% normobaric oxygen with face mask in sitting position, at a flow
rate of 5 liters per minute for 1 hour twice a day for two weeks Functional and structural
outcomes were assessed at 1 and 6 months following treatment. Best corrected visual acuity
was the main outcome measure, and mean deviation index of visual field test and peripapillary
retinal nerve fiber layer thickness were secondary outcome measures.