Outpatient Treatment of Alcohol Withdrawal Syndrome

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare a fixed-schedule therapy versus a symptom-triggered therapy for alcohol withdrawal syndrome in medical outpatients.

Objectives:

• Self-governance in monitoring AWS (alcohol withdrawal syndrome) symptoms and medication

• Clinically controlled trial of two regimens for medical treatment of alcohol withdrawal syndrome

• Outpatient treatment of alcohol withdrawal syndrome

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Treatments: Chlordiazepoxide; Ethanol

Criteria

Inclusion Criteria:

• Patients above the age of 18

• Fulfilled informed consent

• Abstained from alcohol within the last 72 hours.

• Agree on both treatment regimens.

• Abstinence during 10 days (monitoring and medication period), i.e. treatment with disulfiram or oral alcometer test on every attendance (Lion Alcometer S-D2).

Exclusion Criteria:

• Oral alcoholmeter test > 0.1.

• Treatment of AWS within the last week

• 3 earlier attempts at outpatient detoxification within the last 2 months without success.

• Allergy or adverse reactions to chlordiazepoxide

• Treatment with medication in interaction with chlordiazepoxide

• Psychiatric comorbidity within the last year, dependence on other drugs except nicotine dependence

• Medically severe comorbidity, especially severe liver insufficiency

• Severe cardiovascular diseases, NIDDM and IDDM.

• A history within the last year of seizures and delirium tremens.

• Patients should be cooperative in terms of cooperation and understanding of the Danish language.

• Females of fertile age without safe contraception, (i.e. IUD, hormone tablets or sterilisation) also pregnant or breastfeeding women were excluded.