Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
Status:
Not yet recruiting
Trial end date:
2024-09-30
Target enrollment:
Participant gender:
Summary
This study will evaluate changes in blood vessels around the heart (e.g., aorta and carotid
arteries) and in the brain with the loss of female sex hormones (e.g., estrogen) during the
menopause transition. The menopause transition is associated with declines in blood vessel
function and increased risk for cardiovascular disease and Alzheimer's disease. Increasing
evidence supports an early role for declines in blood vessel function and future development
of Alzheimer's disease in aging men and women. This study will learn about the effects of
changes in female sex hormones, such as estrogen, during the menopause transition on blood
vessel around the heart and in the brain in women.