Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency

• Status: Not yet recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: Female

Summary

60 cases with premature ovarian insufficiency will be randomized to either receive PRP or saline injection in their ovaries. Then follow up by hormonal & ultrasound & clinically to monitor any changes

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ahmed Saad
• Collaborator: Hawaa Fertility Center

Criteria

Inclusion Criteria:

• PORs who meet at least two of the following three Bologna criteria

• AMH: 0.1-1 ng/ml.

Exclusion Criteria:

• ovarian insufficiency due to gonadal dysgenesis and -

• chromosomal abnormalities,

• immunoglobulin A deficiency,

• the use of anticoagulants,

• psychotropic medicaments,

• psychiatric disorders,

• carcinomas or

• a history of chronic pelvic pain.

• Women with present infection,

• haemoglobin lower than 11 g/L or

• platelets lower than 150 x 10ʒ/μL were excluded from the study.