Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: Female

Summary

Women with PCOS suffer from excess male hormone (androgen) production by the ovary. Androgen is made by cells that surround follicles that contain eggs. As the follicles (and eggs) grow and mature, there are more androgen producing cells. Women with PCOS have more follicles than normal women and therefore more androgen producing cells. While androgen production has been associated with the number of follicles, the relationship to the individual size of follicles in PCOS or normal women. This study intends to determine whether the size and number of ovarian follicles are correlated to androgen production in PCOS and normal women.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Diego
• Treatments: Androgens; Chorionic Gonadotropin

Criteria

Inclusion Criteria:

1. Subjects will be determined to have PCOS based on clinical history of irregular menses and clinical or laboratory evidence of hyperandrogenism and polycystic ovaries on ultrasound

2. Subjects should not have been on any hormonal therapy or metformin for at least 2 months prior to study start

3. Subjects will be determined to be normal controls if they have a clinical history of regular periods

Exclusion Criteria:

1. Women with hemoglobin less than 11 gm/dl at screening evaluation

2. Women with untreated thyroid abnormalities

3. Pregnant women or women who are nursing

4. Women with BMI > 37

5. Women with known sensitivity to the agents being used

6. Women with diabetes, or renal, liver, or heart disease