Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
Status:
Completed
Trial end date:
2021-06-30
Target enrollment:
Participant gender:
Summary
Women with PCOS suffer from anovulation and, as a result, infertility. Efforts to clinically
induce ovulation in these women using follicle stimulating hormone (FSH) administered
subcutaneously seemingly requires prolonged administration compared to that of ovulatory
women without PCOS. The apparent differing ovarian responsiveness to FSH between PCOS and
normal women has not been carefully studied. We propose to address this issue by performing a
dose-response study and examine ovarian follicle (estrogen, E2) responses to FSH administered
subcutaneously in women with PCOS compared to responses observed in normal women.
Phase:
Phase 4
Details
Lead Sponsor:
University of California, San Diego
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)