Overcoming Membrane Transporters to Improve CNS Drug Delivery - Improving Brain Antioxidants After Traumatic Brain Injury
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
The overall purpose of this research study is to investigate the safety of pharmacological
therapies that may potentially improve pediatric outcomes after traumatic brain injury.
Traumatic brain injuries are the leading cause of death and disability among children and
young adults.
Hypothesis: Combinational therapy with a membrane transporter and antioxidant are safe after
TBI and can overcome barriers to the brain and synergistically improve bioavailability and
efficacy the antioxidant content of the body and CNS after TBI.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Pittsburgh
Collaborators:
National Institute of Neurological Disorders and Stroke (NINDS) National Institutes of Health (NIH)