Ovulation Induction With Clomiphene Citrate and Dexamethasone

• Status: Unknown status
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine if the addition of dexamethasone to clomiphene citrate will increase the pregnancy rate of intrauterine insemination (IUI) cycles.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: San Antonio Military Medical Center
• Treatments: BB 1101; Citric Acid; Clomiphene; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Enclomiphene; Zuclomiphene

Criteria

Inclusion Criteria:

• Active duty military members or dependents seeking infertility treatment at Brooke Army Medical Center

• primary or secondary infertility

• candidate for intrauterine insemination (IUI)

Exclusion Criteria:

• Severe male factor infertility (total motile sperm count <10 million/mL)

• Bilateral fallopian tube obstruction

• Diminished ovarian reserve (baseline follicle stimulating hormone > 20)

• History of clomiphene resistance as determined by a Clomid challenge test or prior non-ovulatory cycles while taking clomiphene

• Known or suspected hypopituitarism or hypothalamic amenorrhea

• Six or more prior therapeutic CC cycles without a pregnancy

• Diabetes

• Renal impairment, hepatitis, hepatic cirrhosis, or myasthenia gravis

• Osteoporosis

• Cataracts or glaucoma

• Congenital Adrenal Hyperplasia, Cushing's disease, or any condition requiring chronic corticosteroid use