Oxaliplatin, Capecitabine, and Bevacizumab Followed By Surgery and/or Radiofrequency Ablation in Patients With Colorectal Cancer

• Status: Withdrawn
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Giving chemotherapy and bevacizumab before surgery or radiofrequency ablation may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

PURPOSE: This phase II trial is studying how well giving oxaliplatin and capecitabine together with bevacizumab followed by surgery and/or radiofrequency ablation works in treating patients with colorectal cancer that has spread to the liver and cannot be removed by surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Davis
• Collaborator: Sanofi
• Treatments: Bevacizumab; Capecitabine; Oxaliplatin

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed colorectal adenocarcinoma metastatic to the liver

• Unresectable liver metastases

• Measurable disease

• No evidence of extrahepatic metastases

• No CNS metastases

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1

• Absolute neutrophil count > 1,500/mm^3

• Platelet count > 100,000/mm^3

• Creatinine ≤ 1.5 times upper limit of normal (ULN) OR creatinine clearance ≥ 45 mL/min

• Urinary protein < 2+ by dipstick OR < 2 g by 24-hour urine collection

• Bilirubin < 2 times ULN

• SGOT and SGPT < 2 times ULN

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 18 months after completion of study therapy

• Able to take oral medications (e.g., no dysphagia or malabsorption symptoms)

• No other prior malignancy unless in complete remission and off therapy for ≥ 5 years

• No known allergy to the study drugs

• No peripheral neuropathy > grade 1

• No uncontrolled infection

• No uncontrolled hypertension

• No active bleeding or hemoptysis

• No other serious concurrent illness within the past 12 months, including any of the following:

• Nonstable coronary artery disease

• Myocardial infarction

• Transient ischemic attack

• Cardiovascular accident

PRIOR CONCURRENT THERAPY:

• Recovered from prior therapy

• At least 28 days since prior major surgery

• Prior therapy for advanced disease allowed

• No prior oxaliplatin-based therapy

• Concurrent maintenance and palliative treatment during study chemotherapy allowed (e.g., nutritional or transfusional support or pain control)

• No concurrent corticosteroids except when used under the following circumstances:

• As oxaliplatin premedication

• Anti-5-HT_3 as antiemetic

• No concurrent cold cap or iced mouth rinses

• No other concurrent chemotherapy

• No placement of hepatic artery port for regional chemotherapy