Oxandrolone Multiligament Knee

• Status: Not yet recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study is about healing after a rmultiligament knee reconstruction procedure. We hope to learn if a biologic medication: Oxandrolone, a synthetic derivative of the human hormone Testosterone (the principal male sex hormone and an anabolic steroid), given for 12 weeks is effective in aiding in the healing process and restoring muscle mass.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: George F. Hatch
• Treatments: Oxandrolone

Criteria

Inclusion Criteria:

• Patients with MRI proven multiligament knee injury scheduled to undergo multiligament knee reconstruction

Exclusion Criteria:

• Patients with prior ipsilateral knee surgery

• Untreated diabetes mellitus

• Pituitary tumor

• Rheumatoid Arthritis

• Uncontrolled hypertension

• Congestive Heart Failure

• Myocardial Infarction within the past 6 months

• End-stage renal disease

• Liver enzymes two times the normal value

• DVT within the past 6 months

• Disorder of the coagulation system

• Currently taking anticoagulation

• Prior or current use of anabolic steroids

• Chromosomal disorders

• Prostate cancer

• Breast cancer

• Hypercalcemia

• Patients with COPD not responsive to bronchodilators

• Patients with known liver disease

• Patients at risk for liver tumors

• Severe hyperlipidemia

• Patients taking medications that interfere with testosterone production or function, including but not limited to 5α-reductase inhibitors, acetaminophen (Tylenol, others), cholesterol lowering