Overview

Oxidative Stress Expression and Metabolic Imbalance in Critically Ill Polytrauma Patients and the Implications of Antioxidant Therapy on Clinical Outcomes

Status:
Unknown status

Trial end date:
2019-12-31

Target enrollment:
0

Participant gender:
All

Summary

Critically ill polytrauma patients have a number of physiological disorders secondary to trauma, such as systemic inflammatory response (SIRS), adult respiratory distress syndrome (ARDS), sepsis, oxidative stress (OS), and finally the multiple organ dysfunction syndrome (MODS). Another important aspect in terms of clinical outcome is the energy-metabolic status. Numerous studies have shown that implementing antioxidant therapy, capable of reducing the expression of pro-oxidative, pro-inflammatory and energetic-metabolic status, the mortality rate in critical patients decreases statistically significant. In this research paper, will be implemented a multimodal monitoring protocol that covers the use of biochemical, genetics and epigenetics biomarkers and the use of non-invasive medical devices to assess and monitor critical polytrauma patient. Also will be optimized the antioxidant treatment plan according to the needs of each patient.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Romanian Society of Anesthesia and Intensive Care

Collaborator:

University of Medicine and Pharmacy "Victor Babes" Timisoara

Treatments:

Antioxidants
Ascorbic Acid
Vitamins

Criteria

Inclusion Criteria:

- ISS > 16

- age >18 y

Exclusion Criteria:

- refused to be enrolled in the study