Complications of hemodialysis access are the most frequent single reason for hospitalization
among patients with End Stage Renal Disease (ESRD). Uremia, and particularly uremia in
patients with diabetes, is a state of increased oxidative stress. The central hypothesis to
be tested by this project is that oxidative stress is a major (and modifiable) trigger for
vascular access complications. We hope to slow or reduce rates of stenosis, thrombosis and
access complications by giving Vitamin E supplementation to patients being treated by
hemodialysis.
Details
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Collaborator:
Leonard B Rosenberg Renal Research Foundation
Treatments:
alpha-Tocopherol Tocopherols Tocotrienols Vitamin E