Oxycodone for Labor Pain - Pharmacokinetics (PK), Safety and Efficacy
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
Childbirth is one of the most painful events that a woman is likely to experience, and thus
is a major concern for most parturient. Severe pain releases stress mediators and may thus
compromise fetus well-being if placental perfusion is decreased. Epidural analgesia is the
golden standard for the management of severe labor pain. However, it could not always be used
both due the parturient related factors and the organizational reasons.However, the knowledge
on safety and efficacy of oxycodone involving mother, fetus and newborn is limited.
Aim of the study is firstly, to evaluate the efficacy and safety of oxycodone in labor pain
healthy parturients. Secondly, to measure parturient's blood oxycodone concentration during
labour and fetal concentration from placental umbilical vein and artery right after birth.