Oxytocin, Carbetocin and Misopristol for Treatment of Postpartum Hemorrhage: A Multicentric Randomized Trial

• Status: Unknown status
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide, with an estimated mortality of 140 000 per year. Uterine atony is one of the most important causes of PPH. The traditional treatment of which is the use of uterotonic agents. Oxytocin is the most conventional drug which was proved effective. However, it has the shortcomings of short half life and the necessity of intravenous administration. Misopristol, and more recently Carbetocin were introduced for treatment of atonic PPP not responding to Oxytocin.

Aim of the study is to evaluate the effectiveness of Carbetocin, Misopristol, and Oxytocin for treatment of atonic PPH.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sohag University
• Collaborator: Al-Azhar University
• Treatments: Carbetocin; Oxytocin

Criteria

Inclusion Criteria:

• primary atonic postpartum hemorrhage after vaginal delivery

Exclusion Criteria:

• Patients who delivered by caesarean section

• Retained placenta

• Traumatic postpartum hemorrhage

• Associated coagulopathy

• Chronic medical illness (hepatic , renal diseases)

• Refusal to participate in the study.