Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
This is a double-blind 3-arm randomized clinical trial to determine whether higher dose
oxytocin regimens (compared to the standard regimen) reduce the frequency of uterine atony
and postpartum hemorrhage after vaginal delivery. Uterine atony is a loss of tone in the
uterine musculature which can cause acute postpartum hemorrhage, which is the major cause of
maternal mortality worldwide. Oxytocin is routinely administered postpartum in the US and
effectively reduces uterine atony. The optimal dose of oxytocin for vaginal delivery is not
known.
Phase:
Phase 4
Details
Lead Sponsor:
University of Alabama at Birmingham
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)