Oxytocin and Eating

• Status: Unknown status
• Trial end date: 2019-01-01
• Target enrollment: 0
• Participant gender: Male

Summary

In this protocol, the investigators propose a randomised controlled trial to explore the effects of intra-nasal oxytocin administration on appetite regulation. The investigators will run a cross-over design with 60 healthy adult men.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale-NUS College
• Collaborators: Singapore General Hospital; SingHealth Investigational Medicine Unit
• Treatments: Oxytocin

Criteria

Inclusion Criteria:

• Gender: Male

• Age: 21-45 years

• Normal weight: Body mass index of 18.5 to 22.9

• Have had a stable weight for the past 3 months (less than 5kg)

• Have regular breakfast meals (≥ 4 times a week of self-reported consumption of a breakfast meal)

• Have habitual sleep of 6.5-8.5 hours

• Have English as first language (or fluent in spoken and written English)

Exclusion Criteria:

• Symptoms / history of any major medical condition, including:

• Bariatric surgery or surgical obesity treatment

• Diabetes

• Cardiovascular disease

• Thyroid disease

• Anaemia

• Psychiatric disorders

• Eating disorders

• Excessive exercise (running > 40 km or exercising > 10 hr in a week)

• Currently on a special diet or trying deliberately to restrict food intake

• Currently on a weight loss program

• Smoking or substance abuse

• Use of medications that can affect weight (e.g., steroids, approved weight-loss drugs)