P2Et Extract in the Symptomatic Treatment of Subjects With COVID-19
Status:
Recruiting
Trial end date:
2021-11-30
Target enrollment:
Participant gender:
Summary
Antioxidants, and particularly polyphenols, have shown protection in respiratory pathologies,
which is related to the decrease in the severity of the clinical picture and suppression of
inflammation. This suppression of inflammation may be related to the inhibition of NF-kB
polyphenols, where its activation is related to the stimulation of 150 stimuli including
cytokines (IL-1β, IL-6, THF-α, GM-CSF, MCP-1), TLRs, among others. There may be other
additional mechanisms that can help control virus-induced respiratory pathologies, among
which are the regulation of reactive oxygen species (ROS) associated with tissue destruction
caused by the virus and a selective antiviral action can be reported. direct.
The standardized P2Et extract obtained from C. spinosa, by the Immunobiology Group of the
Pontificia Universidad Javeriana, is highly antioxidant, decreases lipid peroxidation and
tissue damage and induces complete autophagy in stressed or tumor cells. The induction of a
full autophagic flow could inhibit the replication of beta-coronaviruses like SARS-CoV-2.
Furthermore, P2Et can decrease the factors involved in tissue damage by reducing IL-6 and
decrease ILC2 cells of the lung in animals with lung metastases (unpublished data).
These antecedents suggest that the supplementation of patients with COVID-19 with the extract
P2Et, could improve their general condition and decrease the inflammatory mediators and the
viral load.