PEG-IFN in HBV Patients With Incomplete Response to NA
Status:
Completed
Trial end date:
2012-08-01
Target enrollment:
Participant gender:
Summary
Treatment with a nucleoside analogue and subsequent viral decline has shown to partially
restore immune hyporesponsiveness in chronic hepatitis B patients. Recent pilot studies
investigating whether the effect of lowering viral load with nucleoside analogue therapy
prior to the initiation of peginterferon results in higher sustained off-treatment responses
showed contradictory findings.
The aim of this study is to investigate sustained off-treatment response to peginterferon
alfa-2b in chronic HBeAg-positive hepatitis B patients who are pretreated with nucleos(t)ide
analogues, thereby lowering viral load