PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

• Status: NOT_YET_RECRUITING
• Trial end date: 2042-11-30

Summary

This is a multisite, phase I/II clinical trial in children and young adults with newly-diagnosed high-grade glioma (HGG), diffuse midline glioma (DMG) and recurrent HGG/DMG, Medulloblastoma (MB), or ependymoma (EPN) to determine the safety, immunogenicity, and efficacy of a CMV-directed peptide vaccine plus checkpoint blockade.

• Phase: PHASE1

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborator: National Cancer Institute (NCI)
• Treatments: Nivolumab; Temozolomide