PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome

• Status: Completed
• Trial end date: 2020-05-19
• Target enrollment: 0
• Participant gender: All

Summary

Background:

McCune-Albright Syndrome (MAS) is a disorder that affects the bones, skin, and some hormone-producing tissues. It is associated with a mutation in a gene. This gene affects enzymes in the brain and body. Researchers want to learn more about one of these enzymes, Phosphodiesterase 4 (PDE4), in people with MAS.

Objective:

To see if people with MAS have higher levels of PDE4 than people without MAS.

Eligibility:

People ages 18 and older who have MAS and participated in protocol 98-D-0145, Screening and Natural History of Patients with Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome. Healthy adult volunteers are also needed.

Design:

This study requires 1 to 4 outpatient visits to the NIH Clinical Center. Some visits may take place on the same day.

Participants with MAS will be screened with medical history and physical exam. They will have blood and urine tests.

Participants will have a magnetic resonance imaging scan.

Participants will have a full body positron emission tomography (PET) scan. A small amount of a radioactive chemical, [11C](R)-rolipram, will be given through an intravenous tube.

Participants will have a brain PET scan with [11C](R)-rolipram. For this, a thin plastic tube will also be put into an artery at their wrist or elbow crease area.

For the scans, participants will lie on a bed that slides in and out of a scanner. They may wear a plastic mask to hold their head in place. They will have blood drawn.

Participants with MAS will be interviewed about their thinking and mood. They may complete questionnaires about how they feel or think.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Mental Health (NIMH)
• Treatments: Rolipram

Criteria

• INCLUSION CRITERIA:

Subjects with MAS:

• At least 18 years of age

• Able to provide self-consent

• Diagnosed with MAS under 98-D-0145.

• Have craniofacial fibrous dysplasia

Healthy Subjects:

• At least 18 years of age.

• Healthy based on medical history and physical examination.

EXCLUSION CRITERIA:

Subjects with MAS:

• Serious medical conditions, which may interfere with study procedures. Such conditions include but not limited to significant bone abnormalities in wrist areas of both arms, which makes it difficult to place a radial arterial line, clinically marked dysfunction of liver or kidney, which may delay clearance of [(11)C](R)-rolipram.

• Clinically significant laboratory abnormalities not linked to endocrine abnormalities but that may interfere with the PET measurement or affect safety of the participant during this study.

• Positive HIV test.

• Head trauma resulting in a period of unconsciousness lasting longer than one hour.

• Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.

• Recent research-related exposure to radiation (i.e., PET from other research) that, when combined with this study, would be above the allowable limits.

• Inability to lie flat on camera bed for about two and a half hours.

• Pregnancy or breastfeeding.

• NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.

Healthy Subjects:

• Serious medical conditions, which may interfere with study procedures. Such conditions include but not limited to clinically marked dysfunction of liver or kidney, which may delay clearance of [(11)C](R)-rolipram.

• Clinically significant laboratory abnormalities that may interfere with the PET measurement or affect safety of the participant during this study.

• Personal history of any DSM Axis I disorder.

• Positive HIV test.

• Head trauma resulting in a period of unconsciousness lasting longer than one hour.

• Metallic foreign bodies that would be affected by the MRI magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.

• Recent research-related exposure to radiation (i.e., PET from other research) that, when combined with this study, would be above the allowable limits.

• Inability to lie flat on camera bed for about two and a half hours.

• Pregnancy or breastfeeding.

• Current substance use disorder based on DSM.

• NIMH employees/staff and their immediate family members will be excluded from the study per NIMH policy.