PET/MRI in the Diagnosis of Chronic Pain

• Status: Recruiting
• Trial end date: 2024-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using [18F]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Stanford University
• Collaborator: GE Healthcare

Criteria

Inclusion Criteria:

Healthy Volunteers:

1. At least 18 years old.

Pain Patients:

1. At least 18 years old.

2. Chronic pain (nociceptive, neuropathic or mixed pain) lasting greater than 2 months.

3. Pain level of at least 4/10 on a 0-10 Comparative Pain Scale.

Exclusion Criteria:

Healthy Volunteers:

1. Pain

2. Pain Medication

3. MRI incompatible

4. Pregnant or nursing

5. Non-English speaker

Pain Patients:

1. MRI incompatible

2. Pregnant or nursing

3. Non-English speaker