PET/MRI in the Diagnosis of Pediatric Chronic Pain

• Status: Enrolling by invitation
• Trial end date: 2025-08-01
• Target enrollment: 0
• Participant gender: All

Summary

[18F]FTC-146 is a sigma-1 receptor detector and is an experimental radiotracer. Several studies have implicated involvement of sigma-1 receptors in generation and perpetuation of chronic pain conditions, while others are investigating anti sigma-1 receptor drugs for treatment of chronic pain. Using [18F]-FTC-146 and PET/MRI, we hope to learn what is the best approach to identify the source of pain generation and characterize the disease in pediatric patients with chronic pain.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Collaborator: GE Healthcare

Criteria

Inclusion Criteria:

• 11-18 years old.

• Chronic pain (nociceptive, neuropathic or mixed pain) lasting at least 2 months.

• Pain level of at least 4/10 on a 0-10 Comparative Pain Scale (reported at time of screening).

Exclusion Criteria:

• MRI incompatible

• Pregnant or nursing