PET Study Examining the Dopaminergic Activity of Armodafinil in Adults
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
The specific aims of this study are 1) to document the Dopamine Transporter (DAT) receptor
occupancy of armodafinil using positron emission tomography (PET) scanning with C-11
altropane as the ligand and 2) to document the increased intrasynaptic dopamine produced by
armodafinil using PET scanning with C-11 raclopride as the ligand. We hypothesize that DAT
occupancy will be low with armodafinil; less than the DAT occupancy produced by therapeutic
doses of methylphenidate. We also hypothesize that increases in intrasynaptic dopamine will
be relatively low with armodafinil.