PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

• Status: Terminated
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Danish Headache Center

Criteria

Inclusion Criteria:

• Healthy volunteers,

Exclusion Criteria:

• Primary headache,

• headache on the day of investigation,

• Hypertension,

• hypotension,

• pregnant/nursing

• Daily intake of medication (except oral contraceptives)

• Cardiovascular or CNS disease

• Drug/Alcohol abuse

• Psychiatric disease