PK/PD Levobupivacaine With and Without Epinephrine After Ultrasound Guided ESP Block
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Currently there is no standardized management or single technique to manage postoperative
pain after Video-assisted thoracic surgery (VATS), there are many options available ranging
from intravenous opioids, morphine or fentanyl Patient-controlled analgesia (PCA), peripheral
nerve blocks, intercostals, paravertebral and epidural blocks. Erector Spinal Block (ESP),
this blocks the ventral and dorsal branch of the unilateral thoracic roots. It corresponds to
an interfacial block that produces an extensive multidermatomal sensitive block with a single
puncture, covering the anterior, lateral and posterior aspect of the thorax. One of its main
advantages would be safety, possible less damage to nerves and pneumothorax, as well as the
simplicity of execution of this block. What has positioned it as another analgesic
alternative in this type of surgery.
The pharmacokinetic profile that local anesthetics would have when injected into this
interfacial compartment has not yet been described, and what the real impact of the use of
vasoconstrictor will be in terms of plasma levels and duration of the block.
Our objective is to compare the plasma levels of levobupivacaine achieved after performing an
ESP Block with or without epinephrine.