PK/PD Levobupivacaine With and Without Epinephrine After Ultrasound Guided ESP Block

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Currently there is no standardized management or single technique to manage postoperative pain after Video-assisted thoracic surgery (VATS), there are many options available ranging from intravenous opioids, morphine or fentanyl Patient-controlled analgesia (PCA), peripheral nerve blocks, intercostals, paravertebral and epidural blocks. Erector Spinal Block (ESP), this blocks the ventral and dorsal branch of the unilateral thoracic roots. It corresponds to an interfacial block that produces an extensive multidermatomal sensitive block with a single puncture, covering the anterior, lateral and posterior aspect of the thorax. One of its main advantages would be safety, possible less damage to nerves and pneumothorax, as well as the simplicity of execution of this block. What has positioned it as another analgesic alternative in this type of surgery.

The pharmacokinetic profile that local anesthetics would have when injected into this interfacial compartment has not yet been described, and what the real impact of the use of vasoconstrictor will be in terms of plasma levels and duration of the block.

Our objective is to compare the plasma levels of levobupivacaine achieved after performing an ESP Block with or without epinephrine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pontificia Universidad Catolica de Chile
• Treatments: Bupivacaine; Epinephrine; Epinephryl borate; Levobupivacaine; Racepinephrine

Criteria

Inclusion Criteria:

• Indication of VATS

• ASA I-II

• Body mass index (BMI) 20-34 kg / m2

Exclusion Criteria:

• Patients with conversion to thoracotomy

• History of chronic pain

• Drug abuse

• Psychiatric illness

• Allergic to some of the drugs used in the study

• Chronic analgesic users

• History of peripheral neuropathy

• Who refuse the procedure