PPI Therapy Impact on GERD After Sleeve Gastrectomy

• Status: Not yet recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The trial would to try to establish:

• The best post-operative PPI prescription protocol after Sleeve Gastrectomy

• The impact of PPI therapy on postoperative peptic diseases (erosive gastropathies, ulcers, duodenitis, esophagitis and/or Barrett)

• The impact of PPI therapy on post-operative GERD symptoms (assessed with the use of two standard tests: MRGE-HRQL and GERDQ

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Roma La Sapienza
• Treatments: Dexlansoprazole; Lansoprazole

Criteria

Inclusion Criteria:

• Patients candidates for primary SG

• Patients adhering to the follow-up protocol

• Age between 18 and 65 years

• No BMI limits

Exclusion Criteria:

• Gastric and/or esophageal diseases (routine preoperative endoscopy)

• Patients candidate for revisional bariatric surgery

• Chronic preoperative PPI therapy

• Using of PPI treatment for postoperative complications

• Conversion to open surgery

• Patients allergic to PPI

• Patients undergoing concomitant surgery

• Patients with hiatal hernia undergoing concomitant cruroplasty