PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)

• Status: Completed
• Trial end date: 2019-08-30
• Target enrollment: 0
• Participant gender: All

Summary

This study is aimed at investigating the effect of PPIs on gastroesophageal varices in liver cirrhosis. Half of participants will receive PPI, while the other half will receive a placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yanjing Gao
• Collaborators: Jining NO.1 People 's Hospital; Linyi People 's Hospital; Qingdao University; The Second People 's Hospital of Liaocheng; Zibo City First Hospital
• Treatments: Pantoprazole; Proton Pump Inhibitors

Criteria

Inclusion Criteria:

• Clinical diagnosis of cirrhosis

• GEVs was diagnosed by endoscopy

Exclusion Criteria:

• Acute gastrointestinal bleeding need emergency surgery

• Acid-related disease, such as peptic ulcer disease or gastroesophageal reflux diseases (GERD)

• Hepatocellular carcinoma (HCC) or other malignant tumor

• History of esophagus, stomach or liver surgery

• Child-Pugh C and can't be improved to Child-Pugh A or B

• Preparing to be pregnant, pregnant or breast feeding

• Allergic to PPIs(proton pump inhibitors) or intolerable

• Cannot provide informed consent