PREvention of VENous Thromboembolism In Hemorrhagic Stroke Patients
Status:
Terminated
Trial end date:
2020-03-01
Target enrollment:
Participant gender:
Summary
Patients with cerebral hemorrhage (ICH) have a high risk of venous thromboembolism.
Intermittent pneumatic compression combined with elastic stockings have been shown to be
superior to elastic stockings alone in reducing the rate of asymptomatic deep vein thrombosis
after ICH in a randomized trial (4.7% vs. 15.9%). Graduated compression stockings alone are
ineffective in preventing deep vein thrombosis in patients with ischemic or hemorrhagic
stroke. Less clear is the role of anticoagulation in the prevention of venous thromboembolism
in patients with ICH because the use of anticoagulants may cause an enlargement of the
hematoma. In a multicenter, randomized trial, the investigators will assess the efficacy and
safety of enoxaparin in the prevention of venous thromboembolism in patients with spontaneous
intracerebral hemorrhage. Enoxaparin (40 mg once daily) or standard therapy (graduated
compression stockings and/or intermittent pneumatic compression and/or early mobilization)
will be given subcutaneously for not less than 10 days beginning after 72 hours from stroke
onset.