The current research study aims to compare the effectiveness of two proven treatments for
posttraumatic stress disorder (PTSD): Prolonged Exposure (PE), sertraline, and their
combination. In addition, the investigators are examining predictors of response to these two
treatments and how PTSD symptoms, thoughts, and biological factors may be changed by such
treatments. Biological mechanisms of change are also examined including emotion processing
and regulation in fMRI, HPA axis function, and genetics and genomics. In addition, the
investigators will examine acceptability of each treatment and reasons for ending treatment.
Phase:
Phase 4
Details
Lead Sponsor:
VA Ann Arbor Healthcare System
Collaborators:
U.S. Army Medical Research and Development Command U.S. Army Medical Research and Materiel Command