PRP vs PRP+IVC for Severe nPDR

• Status: Unknown status
• Trial end date: 2021-09-30
• Target enrollment: 0
• Participant gender: All

Summary

The randomized clinical trial aims to compare the therapeutic effects between panretinal photocoagulation(PRP) and PRP combined with intravitreal conbercept (IVC) injection in severe nPDR with/without diabetic macular edema patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ruijin Hospital
• Collaborator: Shanghai Municipal Science and Technology Commission

Criteria

Inclusion Criteria:

Type II diabetic patients, 18 years and older, were included if the participants had:

1. severe non-PDR in either eyes with/without diabetic macular edema;

2. ETDRS letters-measured best-corrected visual acuity (BCVA) ranging from 20/40 to 20/320 Snellen equivalent;

3. no previous treatment (of any type) in either eye.

Exclusion Criteria:

1. history of prior laser treatment or vitrectomy in the study eye;

2. history of thromboembolic event - including myocardial infarction or cerebral vascular accident;

3. major surgery within the prior 6 months or planned within the next 28 days;

4. history of glaucoma or ocular hypertension;

5. loss of vision as a result of other causes;

6. history of systemic corticosteroid therapy within the last 3 months;

7. severe systemic disease other than diabetes mellitus;

8. known coagulation abnormalities or current use of anticoagulative medication other than aspirin

9. any condition that could affect followup or documentation (including preretinal or vitreous hemorrhage).