PaNeX: Partial Nephrectomy Under Xenon

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose of this study is to determine whether Xenon - as compared to Isoflurane - shows a nephroprotection after partial nephrectomy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RWTH Aachen University
• Collaborator: German Research Foundation
• Treatments: Anesthetics; Isoflurane; Xenon

Criteria

Inclusion Criteria:

• Patients willing and able to complete the requirements of this study

• Patients with renal carcinoma restricted to one kidney

• Patients undergoing partial nephrectomy

• Men and women >= 18 yrs

• Informed consent

Exclusion Criteria:

• Chronic renal failure with a GFR < 60ml/min/1,73m2 body surface area

• American Society of Anesthesiologists (ASA)>III

• Hypersensitivity to the study anaesthetics

• Chronic obstructive pulmonary disease (COPD) GOLD IV

• Acute coronary syndrome during the last 24 hours; haemodynamic instability, requirement of inotropic support

• Severe cardial dysfunction New York Heart Association (NYHA) >III

• Disabling neuropsychiatric disorders

• Increased intracranial pressure

• pregnant or breastfeeding women

• Women of childbearing potential

• Presumed uncooperativeness or legal incapacity

• Lack of informed consent

• Participation in a concomitant trial within the last 30 days