Paclitaxel + Carboplatin With/Out Cediranib Maleate in Stage III or Stage IV Non-Small Cell Lung Cancer
Status:
Completed
Trial end date:
2013-01-10
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Cediranib maleate may stop the growth of tumor cells by blocking some of the
enzymes needed for cell growth and by blocking blood flow to the tumor. Giving paclitaxel and
carboplatin together with AZD2171 may kill more tumor cells. It is not yet known whether
giving paclitaxel and carboplatin together with AZD2171 is more effective than giving
paclitaxel and carboplatin together with a placebo in treating non-small cell lung cancer.
PURPOSE: This randomized phase II/III trial is studying how well giving paclitaxel and
carboplatin together with cediranib maleate works and compares it to giving paclitaxel and
carboplatin together with placebo in treating patients with stage III or stage IV non-small
cell lung cancer.