Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU

• Status: Terminated
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive care unit (CICU) usual care, as an initial step toward understanding the best management of sedation in these patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Duke University
• Treatments: Dexmedetomidine; Midazolam; Propofol

Criteria

Inclusion Criteria:

• All patients admitted to the Duke CICU, who require intubation and sedation for mechanical ventilation that is expected to be >24 hours in duration will be included, unless they meet the specified exclusion criteria.

• Patients intubated within one hour prior to care transition to the CICU will also be screened for inclusion.

Exclusion Criteria:

• Exclusion criteria include patients following resuscitation from cardiac arrest who are treated on the cooling protocol

• patients who have suffered a neurologic event (seizure, stroke) or who have baseline dementia, both of which could limit delirium assessment

• patients with child class B and C liver disease

• patients with known allergy to study medications.