Pain Control After Cardiac Surgery Using Intravenous Acetaminophen

• Status: Completed
• Trial end date: 2015-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Acetaminophen; Analgesics, Opioid

Criteria

Inclusion Criteria:

• - Males or females 18 years of age or older.

• Non-emergency cardiac surgery via a midline sternotomy at Cleveland Clinic Main Campus.

Exclusion Criteria:

1. Redo cardiac surgery.

2. Combined CABG (Coronary Artery Bypass Graft)& valve replacement, multiple valve replacements, Ascending aortic or aortic arch surgery.

3. Weight < 50 Kg or Body mass index > 38 kg/m2.

4. Left ventricle EF ¡Ü 35% ,Right ventricular moderate or severe dysfunction.

5. Severe (3-4 +) Tricuspid Regurgitation.

6. Recent stroke (within 6 months).

7. Severe lung disease requiring home O2 therapy.

8. Preoperative renal insufficiency (Creatinine > 2.0) or on dialysis.

9. History of liver cirrhosis or active liver disease.

10. Chronic pain conditions controlled by preoperative opioid administration.

11. Known allergy to acetaminophen or fentanyl.