Pain Control With Total Knee Replacement

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to study the effects of gabapentin on pain control in the perioperative and post-operative period of total knee arthroplasty.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Texas Tech University Health Sciences Center
• Treatments: Gabapentin; gamma-Aminobutyric Acid

Criteria

Inclusion Criteria:

• • Age > 25 years old

• Primary osteoarthritis of the knee

• Must be undergoing unilateral total knee arthroplasty

• Anesthesia assesment score I, II, or III

Exclusion Criteria:

• Severe joint malalignment (defined as varus/valgus angle > 20 deg)

• Use of gabapentin pre-operatively

• History of chronic pain (currently under treatment)

• History of substance abuse

• Impaired kidney function (defined as creatinine > 1.5)

• Epilepsy (currently on medication for treatment)

• Known allergy to Gabapentin

• Known history of depression or suicidal thoughts and behaviors

• Anyone who is not a candidate for general anesthesia or any other portion of the investigator's standard of care.