Pain Management After Transnasal Transsphenoidal Surgery for Pituitary Adenomas

• Status: Recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

We hypothesize that the effects of non-steroidal anti-inflammatory drugs (NSAIDS) for pain relief among patients with pituitary adenomas undergoing transnasal transsphenoidal surgeries are non-inferior to tramadol. We aim to launch a single-center randomized clinical trial to verify this hypothesis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital
• Treatments: Loxoprofen; Parecoxib; Tramadol

Criteria

Inclusion Criteria:

• Patients with pituitary adenomas that need transnasal transsphenoidal surgery

• Patients of either gender aged 18 to 70 years

Exclusion Criteria:

• Patients with rhinitis, sinusitis, deviated nasal septum, etc. that can cause nasal pain

• Patients with medical history of digestive ulcer/gastrointestinal bleeding

• Patients with heart disease, severe liver and kidney dysfunction

• Pregnant patients

• Patients allergic to NSAIDs or tramadol

• Patients who need long-term treatment of NSAIDs or analgesic for other reasons

• Patients whose postoperative paraffin pathology suggests non-pituitary adenoma

• Patients who have not undergone transsphenoidal surgery

• Patients who reject to enter the group or ask to leave the group after entry